Primaquine Diphosphate是一种高效的抗疟药物，对恶性疟原虫配子体具有强效杀灭作用，并能有效预防间日疟和卵形疟的复发。
|
英文别名 (English Synonym) |
Primaquine Diphosphate |
|
中文名称 (Chinese Name) |
磷酸伯氨喹 |
|
靶点 (Target) |
Antimalaria |
|
通路 (Pathway) |
Microbiology/Virology |
|
CAS号 (CAS NO.) |
63-45-6 |
|
分子式 (Formula) |
C15H21N3O·2H3O4P |
|
分子量 (Molecular Weight) |
455.34 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Kim JH, Choi HS, Lee DS. Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation. Int J Mol Sci. 2021 Nov 30;22(23):12961. doi: 10.3390/ijms222312961. PMID: 34884765; PMCID: PMC8657416. [2] Li Q, O'Neil M, Xie L, Caridha D, Zeng Q, Zhang J, Pybus B, Hickman M, Melendez V. Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. Malar J. 2014 Apr 14;13:141. doi: 10.1186/1475-2875-13-141. PMID: 24731238; PMCID: PMC3989846.
