LQZ-7F 作为 survivin二聚化抑制剂，能够剂量依赖性地抑制前列腺癌细胞（PC-3 和 C4-2）的存活，并通过诱导细胞凋亡及与多西紫杉醇的协同作用发挥抗癌效果。

[1] Qi Jing, et al. Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors. Cancer Research. 2016 Jan. 76(2):453-462.[2]Peery R, Cui Q, Kyei-Baffour K, Josephraj S, Huang C, Dong Z, Dai M, Zhang JT, Liu JY. A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. Bioorg Med Chem. 2022 Jul 1;65:116761. doi: 10.1016/j.bmc.2022.116761. Epub 2022 Apr 28. Erratum in: Bioorg Med Chem. 2023 Jan 15;78:117127. doi: 10.1016/j.bmc.2022.117127. PMID: 35504208; PMCID: PMC9148172.