PD-L1-IN-3（化合物4a）是一种高效的PD-1/PD-L1小分子抑制剂，在Jurkat T细胞中的EC50为2.70 μM。该化合物通过结合PD-L1二聚体，阻断PD-1/PD-L1相互作用及下游信号传导，在肺癌和黑色素瘤等疾病研究中具有应用潜力

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2~8℃避光保存，有效期3年。

[1] Ważyńska MA, Butera R, Requesens M, Plat A, Zarganes-Tzitzikas T, Neochoritis CG, Plewka J, Skalniak L, Kocik-Krol J, Musielak B, Magiera-Mularz K, Rodriguez I, Blok SN, de Bruyn M, Nijman HW, Elsinga PH, Holak TA, Dömling A. Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. J Med Chem. 2023 Jul 27;66(14):9577-9591. doi: 10.1021/acs.jmedchem.3c00254. Epub 2023 Jul 14. PMID: 37450644; PMCID: PMC10388299.