NP10679是一种口服生物利用度高、脑穿透性良好的选择性 pH 依赖性 GluN2B 亚基特异性 NMDA 受体抑制剂。该化合物同时具有组胺 H1 受体拮抗作用、hERG 通道抑制活性，并可逆地抑制人肝脏 CYP酶。

[1] Myers SJ, Ruppa KP, Wilson LJ, Tahirovic YA, Lyuboslavsky P, Menaldino DS, Dentmon ZW, Koszalka GW, Zaczek R, Dingledine RJ, Traynelis SF, Liotta DC. A Glutamate N-Methyl-d-Aspartate (NMDA) Receptor Subunit 2B-Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use. J Pharmacol Exp Ther. 2021 Oct;379(1):41-52. doi: 10.1124/jpet.120.000370. Epub 2021 Sep 7. PMID: 34493631; PMCID: PMC8626636.