UCL 1684 (dibromide)能有效预防房颤,其作为一种SK通道阻滞剂,兼具心房选择性INa抑制及通过诱导后除极耐受来延长ERP的作用。
[1] Burashnikov A, Barajas-Martinez H, Hu D, Robinson VM, Grunnet M, Antzelevitch C. The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020 Aug;76(2):164-172. doi: 10.1097/FJC.0000000000000855. PMID: 32453071; PMCID: PMC7416459.[2]Diness JG, Skibsbye L, Jespersen T, Bartels ED, Sørensen US, Hansen RS, Grunnet M. Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition. Hypertension. 2011 Jun;57(6):1129-35. doi: 10.1161/HYPERTENSIONAHA.111.170613. Epub 2011 Apr 18. PMID: 21502564.





