氟芬那酸是一种非甾体抗炎药，具有多重作用机制：不仅能抑制环氧合酶（COX）和激活AMPK，还可调节多种离子通道（如阻断氯离子通道和L-型钙通道，激活钾通道）；最新研究发现它还能与转录因子TEAD2的YAP结合域结合，抑制TEAD功能及其介导的细胞迁移和增殖。
|
英文别名 (English Synonym) |
Flufenamic acid |
|
中文名称 (Chinese Name) |
氟芬那酸 |
|
靶点 (Target) |
AMPK; Calcium Channel; Chloride Channel; COX; Potassium Channel |
|
通路 (Pathway) |
Immunology/Inflammation |
|
CAS号 (CAS NO.) |
530-78-9 |
|
分子式 (Formula) |
C14H10F3NO2 |
|
分子量 (Molecular Weight) |
281.23 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Pongkorpsakol P, Satitsri S, Wongkrasant P, Chittavanich P, Kittayaruksakul S, Srimanote P, Chatsudthipong V, Muanprasat C. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5;798:94-104. doi: 10.1016/j.ejphar.2017.01.026. Epub 2017 Jan 21. PMID: 28119077.
