OSU-03012(AR-12) PDK-1抑制剂/PDK1抑制剂|CAS 742112-33-0（53397ES）

OSU-03012 (AR-12; OSU03012; AR12)是一种有效的PDK-1抑制剂（phosphoinositide-dependent kinase 1抑制剂）其IC₅₀值为5 μM，抑制效能比OSU-02067作用效果高2倍。

参考文献

[1] Zhu J1, et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 Jun 15;64(12):4309-18.

[2] Lee TX1, et al. Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. Eur J Cancer. 2009 Jun;45(9):1709-20.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。