Nesbuvir通过靶向丙型肝炎病毒(HCV)的NS5B聚合酶，发挥非核苷抑制作用。

[1] Flint M, Mullen S, Deatly AM, Chen W, Miller LZ, Ralston R, Broom C, Emini EA, Howe AY. Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034). Antimicrob Agents Chemother. 2009 Feb;53(2):401-11. doi: 10.1128/AAC.01081-08. Epub 2008 Oct 20. PMID: 18936191; PMCID: PMC2630598.[2]Reich S, Golbik RP, Geissler R, Lilie H, Behrens SE. Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem. 2010 Apr 30;285(18):13685-93. doi: 10.1074/jbc.M109.082206. Epub 2010 Mar 1. PMID: 20194503; PMCID: PMC2859531.