(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine)是一种高效且选择性的 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂。在动物层面,该化合物能够诱导小鼠产生癫痫发作反应,并引起 Fos 蛋白的表达。
[1] Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. Eur J Pharmacol. 1991 Oct 15;203(2):237-43. doi: 10.1016/0014-2999(91)90719-7. PMID: 1686860.[2]Ong WY, Motin LG, Hansen MA, Dias LS, Ayrout C, Bennett MR, Balcar VJ. P2 purinoceptor blocker suramin antagonises NMDA receptors and protects against excitatory behaviour caused by NMDA receptor agonist (RS)-(tetrazol-5-yl)-glycine in rats. J Neurosci Res. 1997 Sep 1;49(5):627-38. doi: 10.1002/(SICI)1097-4547(19970901)49:5<627::AID-JNR13>3.0.CO;2-S. PMID: 9302084.





