ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

推荐稀释比 WB:1/500-1/1000;IHC:1/100-1/200;IF:1/50-1/200;FC:1/50-1/100

Western blot analysis of ABCG2 (2F7) in NIH/3T3 and Cos7 lysates using ABCG2 (2F7) antibody.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.