Thiophenicol通过结合细菌50S核糖体亚基、抑制蛋白质合成而发挥广谱抑菌作用。该药是氯霉素的衍生物,对革兰氏阴性与阳性需氧菌、厌氧菌均有效。
|
英文别名 (English Synonym) |
Thiamphenicol |
|
中文名称 (Chinese Name) |
甲砜霉素 |
|
靶点 (Target) |
Anti-infection |
|
通路 (Pathway) |
Microbiology/Virology |
|
CAS号 (CAS NO.) |
15318-45-3 |
|
分子式 (Formula) |
C12H15Cl2NO5S |
|
分子量 (Molecular Weight) |
356.22 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Marchese A, Debbia EA, Tonoli E, Gualco L, Schito AM. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec,14(6):554-61. doi: 10.1179/joc.2002.14.6.554. PMID: 12583545.[2]Tikhomirov M, Poźniak B, Smutkiewicz A, Świtała M. Pharmacokinetics of florfenicol and thiamphenicol in ducks. J Vet Pharmacol Ther. 2019 Jan,42(1):116-120. doi: 10.1111/jvp.12714. Epub 2018 Sep 21. PMID: 30242846.
