Diphenidol hydrochloride是一种抗眩晕和止吐药物,其通过非选择性拮抗毒蕈碱 M1-M4 受体及有效阻断神经细胞电压门控 Na+、K+、Ca2+ 离子通道发挥作用。
|
英文别名 (English Synonym) |
Diphenidol hydrochloride |
|
中文名称 (Chinese Name) |
盐酸地芬尼多 |
|
靶点 (Target) |
AChR |
|
通路 (Pathway) |
Neuroscience |
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CAS号 (CAS NO.) |
3254-89-5 |
|
分子式 (Formula) |
C21H28ClNO |
|
分子量 (Molecular Weight) |
345.91 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Leung YM, Wu BT, Chen YC, Hung CH, Chen YW. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun,58(7):1147-52. doi: 10.1016/j.neuropharm.2010.02.007. Epub 2010 Feb 20. PMID: 20176039.[2]Chen YW, Tzeng JI, Liu KS, Yu SH, Hung CH, Wang JJ. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27,552:62-5. doi: 10.1016/j.neulet.2013.07.030. Epub 2013 Jul 31. PMID: 23916656.
