Dantrolene sodium是一种口服活性钙通道蛋白抑制剂,其通过非竞争性抑制谷胱甘肽还原酶发挥作用。它能够抑制RyR1和RyR3介导的钙离子释放,从而改善钙稳态破坏引起的多种病理状态,如中风、缺血/再灌注损伤及神经退行性疾病。此外,该化合物还具备缓解肌肉痉挛、治疗恶性高热、解毒、镇痛及抗炎等多种功效。
|
英文别名 (English Synonym) |
Dantrolene sodium |
|
中文名称 (Chinese Name) |
硝苯呋海因钠；丹曲林钠 |
|
靶点 (Target) |
Calcium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
14663-23-1 |
|
分子式 (Formula) |
C14H9N4NaO5 |
|
分子量 (Molecular Weight) |
336.23 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Choi RH, Koenig X, Launikonis BS. Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proc Natl Acad Sci U S A. 2017 May 2,114(18):4811-4815. doi: 10.1073/pnas.1619835114. Epub 2017 Apr 3. PMID: 28373535, PMCID: PMC5422773.[2]Osipchuk NC, Soulika AM, Fomina AF. Modulation of Ryanodine Receptors Activity Alters the Course of Experimental Autoimmune Encephalomyelitis in Mice. Front Physiol. 2021 Dec 17,12:770820. doi: 10.3389/fphys.2021.770820. PMID: 35027891, PMCID: PMC8751758.
