Palonosetron hydrochloride作为一种 5-HT3 拮抗剂,除主要用于预防化疗相关的急性、延迟性及整体恶心呕吐外,还表现出抗抑郁活性,并在哺乳动物细胞中显示出中等的抗黄病毒作用及高效的抗寨卡病毒活性。
|
英文别名 (English Synonym) |
Palonosetron HCl |
|
中文名称 (Chinese Name) |
盐酸帕洛诺司琼 |
|
靶点 (Target) |
5-HT Receptor |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
135729-62-3 |
|
分子式 (Formula) |
C19H25ClN2O |
|
分子量 (Molecular Weight) |
332.87 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于H2O |
-25~-15℃保存，有效期3年
[1] Rojas C, Li Y, Zhang J, Stathis M, Alt J, Thomas AG, Cantoreggi S, Sebastiani S, Pietra C, Slusher BS. The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J Pharmacol Exp Ther. 2010 Nov,335(2):362-8. doi: 10.1124/jpet.110.166181. Epub 2010 Aug 19. PMID: 20724484, PMCID: PMC3202469.[2]Sharma J, et al. Evaluation of antidepressant effect of palonosetron in Swiss albino mice[J]. National Journal of Pharmacology and Therapeutics, 2023, 1(2): 98-100.
