Benidipine hydrochloride是一种口服钙通道拮抗剂,它通过抑制细胞增殖、促进凋亡、发挥抗氧化作用以及增强一氧化氮合酶活性,最终改善高血压大鼠的冠状动脉循环。
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英文别名 (English Synonym) |
Benidipine hydrochloride |
|
中文名称 (Chinese Name) |
盐酸贝尼地平 |
|
靶点 (Target) |
Calcium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
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CAS号 (CAS NO.) |
91599-74-5 |
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分子式 (Formula) |
C28H31N3O6·HCl |
|
分子量 (Molecular Weight) |
542.02 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Ono T, Liu N, Kusano H, Nogaki F, Makino T, Muso E, Sasayama S. Broad antiproliferative effects of benidipine on cultured human mesangial cells in cell cycle phases. Am J Nephrol. 2002 Sep-Dec,22(5-6):581-6. doi: 10.1159/000065266. PMID: 12381964.[2]Kobayashi N, Kobayashi K, Hara K, Higashi T, Yanaka H, Yagi S, Matsuoka H. Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats. Am J Hypertens. 1999 May,12(5):483-91. doi: 10.1016/s0895-7061(98)00260-x. PMID: 10342786.
