Vardenafil hydrochloride trihydrate是一种高选择性、口服活性的PDE5抑制剂,其对PDE1/PDE6的抑制活性较低,而对PDE3/4无显著抑制。它通过非竞争性抑制cGMP水解来提高cGMP水平,可用于勃起功能障碍、肝炎及糖尿病等疾病的研究。
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英文别名 (English Synonym) |
Vardenafil HCl Trihydrate |
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中文名称 (Chinese Name) |
伐地那非盐酸盐水合物；盐酸瓦地那非三水合物 |
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靶点 (Target) |
PDE |
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通路 (Pathway) |
Protease/Metabolic Enzyme |
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CAS号 (CAS NO.) |
330808-88-3 |
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分子式 (Formula) |
C23H32N6O4S·HCl·3H2O |
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分子量 (Molecular Weight) |
579.11 |
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纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Gresser U, Gleiter CH. Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature. Eur J Med Res. 2002 Oct 29,7(10):435-46. PMID: 12435622.[2]Oudot A, Behr-Roussel D, Poirier S, Sandner P, Bernabé J, Alexandre L, Giuliano F. Combination of BAY 60-4552 and vardenafil exerts proerectile facilitator effects in rats with cavernous nerve injury: a proof of concept study for the treatment of phosphodiesterase type 5 inhibitor failure. Eur Urol. 2011 Nov,60(5):1020-6. doi: 10.1016/j.eururo.2011.07.052. Epub 2011 Jul 30. PMID: 21839578.
