Mizolastine作为第二代口服高选择性外周组胺H1受体拮抗剂，能有效抑制VEGF165、VEGF120、TNF-α及KC等炎症因子的mRNA表达，在过敏性鼻炎和慢性特发性荨麻疹的病理机制研究及治疗策略开发中具有重要价值。
|
英文别名 (English Synonym) |
Mizolastine |
|
中文名称 (Chinese Name) |
咪唑斯汀 |
|
靶点 (Target) |
Histamine Receptor |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
108612-45-9 |
|
分子式 (Formula) |
C24H25FN6O |
|
分子量 (Molecular Weight) |
432.49 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Xia Q, Yang S, Zhang SQ, Chen B, Wang DB, Zhu QX, Wang Y, Yan KL, He PP, Zhang XJ. The effect of mizolastine on expression of vascular endothelial cell growth factor, tumour necrosis factor-alpha and keratinocyte-derived chemokine in murine mast cells, compared with dexamethasone and loratadine. Clin Exp Dermatol. 2005 Mar;30(2):165-70. doi: 10.1111/j.1365-2230.2005.01721.x. PMID: 15725247.[2] Ren X, Zhang M, Chen L, Zhang W, Huang Y, Luo H, Li L, He H. The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model. Mol Med Rep. 2017 Oct;16(4):4045-4053. doi: 10.3892/mmr.2017.7104. Epub 2017 Jul 27. PMID: 28765972; PMCID: PMC5647098.
