Indapamide作为口服有效的磺胺类利尿剂，通过降低血管反应性与外周阻力发挥降压作用，并能显著改善左心室肥厚病变。
|
英文别名 (English Synonym) |
Indapamide |
|
中文名称 (Chinese Name) |
吲达帕胺 |
|
靶点 (Target) |
Potassium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
26807-65-8 |
|
分子式 (Formula) |
C16H16ClN3O3S |
|
分子量 (Molecular Weight) |
365.83 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Furman BL, Razak TB. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33(11):735-7. doi: 10.1111/j.2042-7158.1981.tb13918.x. PMID: 6118417. [2] Ma F, Lin F, Chen C, Cheng J, Zeldin DC, Wang Y, Wang DW. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84(2):286-95. doi: 10.1124/mol.113.085878. Epub 2013 May 31. PMID: 23729436; PMCID: PMC3716319.
