Verapamil hydrochloride ((±)-Verapamil hydrochloride)作为钙通道阻滞剂及第一代P-糖蛋白口服抑制剂，通过抑制CYP3A4酶活性调节药物代谢，在高血压、心律失常和心绞痛的病理机制研究及治疗策略开发中具有重要应用价值。
|
英文别名 (English Synonym) |
Verapamil HCl |
|
中文名称 (Chinese Name) |
盐酸维拉帕米 |
|
靶点 (Target) |
Calcium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
152-11-4 |
|
分子式 (Formula) |
C27H39ClN2O4 |
|
分子量 (Molecular Weight) |
491.06 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Rehnqvist N, Hjemdahl P, Billing E, Björkander I, Eriksson SV, Forslund L, Held C, Näsman P, Wallén NH. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81. doi: 10.1093/oxfordjournals.eurheartj.a014695. Erratum in: Eur Heart J 1996 Mar;17(3):483. PMID: 8682134. [2] Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2(Suppl 2):183S-189S. doi: 10.1111/j.1365-2125.1986.tb02869.x. PMID: 3530300; PMCID: PMC1400728.
