Diatrizoic acid作为一种含碘造影剂，在气道放射成像中具有应用潜力。该化合物可通过干扰钙稳态诱导线粒体功能紊乱和氧化应激反应，进而激活细胞凋亡通路。
|
英文别名 (English Synonym) |
Diatrizoic acid |
|
中文名称 (Chinese Name) |
泛影酸 |
|
靶点 (Target) |
Others |
|
通路 (Pathway) |
Others |
|
CAS号 (CAS NO.) |
117-96-4 |
|
分子式 (Formula) |
C11H9I3N2O4 |
|
分子量 (Molecular Weight) |
613.91 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Ward DB, Brown KC, Valentovic MA. Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation. Int J Mol Sci. 2019 Aug 21;20(17):4074. doi: 10.3390/ijms20174074. PMID: 31438500; PMCID: PMC6747199. [2] El-Gendy N, Aillon KL, Berkland C. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12. doi: 10.1016/j.ijpharm.2010.03.009. Epub 2010 Mar 7. PMID: 20214960; PMCID: PMC2859999.
