盐酸氟桂利嗪是一种Na+/Ca2+（T型）通道双重阻滞剂和D2多巴胺受体拮抗剂，具有抗惊厥、抗偏头痛活性及外周血管扩张作用。
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英文别名 (English Synonym) |
Flunarizine dihydrochloride |
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中文名称 (Chinese Name) |
盐酸氟桂利嗪 |
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靶点 (Target) |
Calcium Channel |
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通路 (Pathway) |
Membrane Transporter/Ion Channel |
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CAS号 (CAS NO.) |
30484-77-6 |
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分子式 (Formula) |
C26H26F2N2·2HCl |
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分子量 (Molecular Weight) |
477.42 |
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纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Novalbos J, Abad-Santos F, Zapater P, Cano-Abad MF, Moradiellos J, Sánchez-García P, García AG. Effects of dotarizine and flunarizine on chromaffin cell viability and cytosolic Ca2+. Eur J Pharmacol. 1999 Feb 5;366(2-3):309-17. doi: 10.1016/s0014-2999(98)00916-9. PMID: 10082213.[2]Wan L, Wu W, Jiang S, Wan S, Meng D, Wang Z, Zhang J, Wei L, Yu P. Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury. Mediators Inflamm. 2020 Nov 10;2020:3691701. doi: 10.1155/2020/3691701. PMID: 33223955; PMCID: PMC7671802.
