盐酸昂丹司琼（GR 38032；SN 307）是一种高选择性的5-HT3受体拮抗剂（IC50=103 pM），它通过阻断外周和中枢神经系统中的5-HT3受体，有效抑制由化疗和放疗引起的恶心和呕吐。
|
英文别名 (English Synonym) |
Ondansetron HCl |
|
中文名称 (Chinese Name) |
盐酸昂丹司琼 |
|
靶点 (Target) |
5-HT Receptor |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
99614-01-4 |
|
分子式 (Formula) |
C18H19N3O·HCl |
|
分子量 (Molecular Weight) |
329.82 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] 허원석. (2014). Effects of ondansetron on the activity of glutamate transporter type 3 and the modulation mechanism[Doctoral dissertation, Seoul National University].[2]Khedhaier A, Ben Attia M, Gadacha W, Sani M, Bouzouita K, Chouchane L, Mechkouri M, Reinberg A, Boughattas NA. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16. doi: 10.1081/cbi-120025532. PMID: 14680146.
