氯沙坦是一种血管紧张素II受体拮抗剂，它通过竞争性结合AT1受体（IC50=20 nM）来阻断血管紧张素II的作用。
|
英文别名 (English Synonym) |
Losartan |
|
中文名称 (Chinese Name) |
氯沙坦 |
|
靶点 (Target) |
Angiotensin Receptor |
|
通路 (Pathway) |
GPCR/G protein |
|
CAS号 (CAS NO.) |
114798-26-4 |
|
分子式 (Formula) |
C22H23ClN6O |
|
分子量 (Molecular Weight) |
422.91 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Ashry O, Schnecko A, Clauss WG, Fronius M. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol. 2014 May 1;195:37-40. doi: 10.1016/j.resp.2014.02.001. Epub 2014 Feb 12. PMID: 24530803.[2]Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science. 2006 Apr 7;312(5770):117-21. doi: 10.1126/science.1124287. PMID: 16601194; PMCID: PMC1482474.
