MC1568 (MC-1568)是II类HDAC选择性抑制剂，可以抑制HDAC4和HDAC6活性。MC1568通过调节HDAC-MEF2复合物的稳定性和活性抑制肌肉发生。

参考文献

[1] Mai A, et al. Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. J Med Chem. 2005 May 5;48(9):3344-53.

[2] Duong V, et al. Specific activity of class II histone deacetylases in human breast cancer cells. Mol Cancer Res. 2008 Dec;6(12):1908-19.

[3] Nebbioso A, et al. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO Rep. 2009 Jul;10(7):776-82.

[4] Nebbioso A, et al. HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation. J Mol Endocrinol. 2010 Oct;45(4):219-28.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。