Tranylcypromine (2-PCPA, SKF-385) hydrochloride,又称反苯环丙胺盐酸盐,由苯丙胺侧链环化形成的丙胺,是一种非选择性的不可逆的单胺氧化酶(MAO)抑制剂,作用于MAO-A/B的IC50为2.3 μM和0.95 μM,可用于治疗抑郁症。
参考文献
1.Zhang W, et al. Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Drug Metab Dispos. 2001 Jun;29(6):897-902.
2.Hong SL, et al. Tranylcypromine and 15-hydroperoxyarachidonate affect arachidonic acid release in addition to inhibition of prostacyclin synthesis in calf aortic endothelial cells. J Biol Chem. 1980 Oct 25;255(20):9538-40.
3.Taavitsainen P, et al. In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. Drug Metab Dispos. 2001 Mar;29(3):217-22.
冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。





