GANT 58 (NSC 75503, NSC75503, GANT58)是细胞通透性GLI拮抗剂，抑制GLI1诱导的基因反式激活转录，IC₅₀值为5 μM。GANT 58对于Hedgehog信号通路具有高选择性，具有潜在抗癌作用。Hedgehog信号在胚胎时期的细胞分化、组织发育及器官形成中有重要作用。

参考文献

1.Lauth M, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.

2.Hou X, et al. Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells. Biochimie. 2014, 101:50-9.

3.Joo J, et al. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One. 2009 Oct 27;4(10):e7608.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。