UNC8153是一种通过蛋白酶体依赖性途径降解NSD2的选择性降解剂,并能降低H3K36me2染色质标记水平。

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-25~-15℃避光保存，有效期3年。

[1] Hanley RP, Nie DY, Tabor JR, Li F, Sobh A, Xu C, Barker NK, Dilworth D, Hajian T, Gibson E, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Herring LE, Wang GG, Licht JD, Vedadi M, Arrowsmith CH, James LI. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12,145(14):8176-8188. doi: 10.1021/jacs.3c01421. Epub 2023 Mar 28. PMID: 36976643, PMCID: PMC10116495.