Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3, 4, 5)P3 > PtdIns(3, 4)P2 > PtdIns3P > Ins(1, 3, 4, 5)P4.

推荐稀释比 WB:1/1000-1/2000; IHC:1/100-1/200; IF:1/50-1/200

Western blot analysis of PTEN in HeLa，NIH/3T3，C6 lysates using PTEN antibody.

Western blot analysis of PTEN in 293T and Hela lysates using PTEN antibody.

Immunohistochemistry analysis of paraffin-embedded Human colon using PTEN antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescence analysis of PTEN in Hela using PTEN antibody.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.