AIRE (Autoimmune Regulator) is a key transcription factor that regulates autoimmune tolerance in medullary thymic epithelial cells (mTECs). It mediates the negative selection of T cells by promoting the expression of tissue-specific antigens (TSAs). Phosphorylation at Ser156 is an important post-translational modification for the functional regulation of AIRE, affecting its transcriptional activity and protein stability.

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