Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200

Western blot analysis of Phospho-RSK1 p90 (Thr348) in Hela lysates untreated or treated with UV using p90RSK (Phospho-Thr348) antibody.

Immunofluorescence analysis of Phospho-RSK1 p90 (Thr348) in Hela using p90RSK (Phospho-Thr348) antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue using p9RSK (Phospho-Thr348) antibody (left) or the same antibody preincubated with blocking peptide (right).High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.