Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes .

推荐稀释比 WB:1/500-1/1000

Western blot analysis of TRIM23 in K562, C6, 3T3, Hela lysates using TRIM23 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。