The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of CLCN7 in LoVo and A549, mouse liver and rat liver lysates using CLCN7 antibody

Western blot analysis of CLCN7 in HepG2, A549, LOVO lysates using CLCN7 antibody.

Immunohistochemistry analysis of paraffin-embedded Human esophagus cancer using CLCN7 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.