Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of PTPN22 in mouse muscle lysates using PTPN22 antibody

Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer using PTPN22 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.