SCH772984 (SCH-772984)是一种新型高选择性、ATP竞争性的ERK1/2抑制剂，IC₅₀分别为4 nM和1 nM，强烈抑制含有RAS或BRAF突变的癌细胞的生长。此外，SCH772984对7种激酶（MAP4K4、MAPK1、CLK2、GSG2、FLT4、MINK1、PRKD1和TTK）具有高选择性，在1 μM浓度时抑制超过50%的活性。

参考文献

[1].Morris EJ, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013;3(7):742-50.

[2].Wong DJL, et al. Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma. Molecular cancer, 2014;13(1): 194.

[3].Hu C, et al. Combined inhibition of cyclin-dependent kinases (Dinaciclib) and AKT (MK-2206) or ERK (SCH772984) dramatically blocks pancreatic tumor growth and metastases in patient-derived orthotopic xenograft models. Mol Cancer Ther. 2015;14(7):1532-9.

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