长期暴露二硫化钼纳米片诱导肝脏脂质积累和动脉粥样硬化的血管毒性研究

Abstract

Before their large-scale applications, it is necessary to understand the biological effects of nanomaterials. Although two-dimensional nanomaterials (2D NMs) molybdenum disulfide nanosheets (MoS 2 NSs) are promising in biomedical fields, the current knowledge regarding their toxicities is inadequate. Using apolipoprotein E deficient (ApoE −/− ) mice as a long-term exposure model, this study demonstrated that intravenous ( i.v. ) injection of MoS 2 NSs most accumulated in the liver and caused in situ hepatic damage. Histopathological examination indicated severe infiltration of inflammatory cells and irregular central veins in the MoS 2 NSs-treated mouse liver. Meanwhile, the overwhelming expressions of inflammatory cytokines, dyslipidemia, and dysregulated hepatic lipid metabolism implied the potential vascular toxicity of MoS 2 NSs. Indeed, our result supported that MoS 2 NSs exposure is highly associated with atherosclerotic progression. This study provided the first line of evidence on the vascular toxicity of MoS 2 NSs, which remind scientists to pay attention to the rational use of MoS 2 NSs, especially in the biomedical fields.