miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
Xuehui Wang, Zhilu Yao, Lin Fang
Journal：PPAR Research
IF：4.96
DOI：10.1155/2021/6661828
PMID：33777130
Published：2021-03-13
research field：神经科学分子生物学微生物学
Abstract
In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1β and finally regulate the PPARγ pathway in BC. In conclusion, miR-22-3p/PGC1β suppresses BC cell tumorigenesis via PPARγ, which may become a potential biomarker and therapeutic target.
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