ANA-12是TrkB选择性拮抗剂，在高亲和力位点和低亲和力位点的IC₅₀值分别为45.6 nM和41.1 μM，选择性地与TrkB结合并抑制TrkB下游的过程，可阻止BDNF受体激活，但不会改变TrkA和TrkC的功能。

参考文献

[1] Cazorla M, Prémont J, Mann A, et, al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011 May;121(5):1846-57. doi: 10.1172/JCI43992(IF:12.28).

[2] Zhang JC, Wu J, Fujita Y, et, al. Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol. 2014 Oct 31;18(4):pyu077. doi: 10.1093/ijnp/pyu077(IF:4.207).

-25~-15℃保存，有效期3年。