Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C), also known as B-cell-activating factor receptor (BAFFR) or CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFFR promotes B cell survival and is crucial for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B), and BAFF receptor (BAFFR/BR3/TNFRSF13C). These receptors are type III transmembrane proteins without a signal peptide. BAFFR is highly expressed in the spleen, lymph nodes, and resting B cells, and at lower levels in activated B cells, resting CD4+ T cells, the thymus, and peripheral blood leukocytes. BAFF knockout mice lack mature B cells, as do A/WySnJ mice with defects in BAFF-R intracellular signaling, indicating that BAFFR is the critical receptor for BAFF during B lymphopoiesis. It is hypothesized that elevated levels of BAFFR/TNFRSF13C (CD268) may contribute to autoimmune disease pathogenesis by enhancing the survival of autoreactive B cells.

高纯度、高活性、低内毒素、高批间一致性

                            SDS-PAGE

      1μg (R: reducing condition, N: non-reducing condition).

Figure 1.The purity of Human BAFFR is greater than 95% as determined by SDS-PAGE.

                               SEC-HPLC

The purity of  Human BAFFR Fc Chimera Protein is greater than 95% as determined by SEC-HPLC.

                                        ELISA

Immobilized Human BAFFR Fc Chimera Protein  at 1.0μg/mL (100μL/well) can bind Biotinylated BAFF Protein, human with EC50 of 1.36-1.52 ng/mL.

-25 ~ -15℃保存，收到货之后有效期1年。
复溶后，无菌条件下，2~8℃保存，7天有效期。复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。