Pergolide mesylate是一种具有口服活性的Ergoline衍生物,作为多巴胺D1与D2受体的有效激动剂,可用于帕金森氏病和高泌乳素血症的研究。
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英文别名 (English Synonym) |
Pergolide mesylate |
|
中文名称 (Chinese Name) |
甲磺酸培高利特 |
|
靶点 (Target) |
Dopamine Receptor |
|
通路 (Pathway) |
Neuroscience |
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CAS号 (CAS NO.) |
66104-23-2 |
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分子式 (Formula) |
C19H26N2S·CH4O3S |
|
分子量 (Molecular Weight) |
410.59 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Uberti D, Piccioni L, Colzi A, Bravi D, Canonico PL, Memo M. Pergolide protects SH-SY5Y cells against neurodegeneration induced by H(2)O(2). Eur J Pharmacol. 2002 Jan 2,434(1-2):17-20. doi: 10.1016/s0014-2999(01)01537-0. PMID: 11755160.[2]Ciobica A, Olteanu Z, Padurariu M, Hritcu L. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease. J Physiol Biochem. 2012 Mar,68(1):59-69. doi: 10.1007/s13105-011-0119-x. Epub 2011 Oct 18. PMID: 22006204.
