三苯乙酸盐维兰特罗（GW642444）是一种长效β2-肾上腺素受体（β2-AR）激动剂，对β2-AR、β1-AR和β3-AR的pEC50值分别为9.4、6.4和6.1，它通过选择性激活气道β2-AR、升高cAMP水平来舒张支气管平滑肌，可用于哮喘的相关研究。
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英文别名 (English Synonym) |
Vilanterol trifenatate |
|
中文名称 (Chinese Name) |
维兰特罗 |
|
靶点 (Target) |
Adrenergic Receptor |
|
通路 (Pathway) |
GPCR/G protein |
|
CAS号 (CAS NO.) |
503070-58-4 |
|
分子式 (Formula) |
C44H49Cl2NO7 |
|
分子量 (Molecular Weight) |
774.77 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Procopiou PA, Barrett VJ, Bevan NJ, Biggadike K, Box PC, Butchers PR, Coe DM, Conroy R, Emmons A, Ford AJ, Holmes DS, Horsley H, Kerr F, Li-Kwai-Cheung AM, Looker BE, Mann IS, McLay IM, Morrison VS, Mutch PJ, Smith CE, Tomlin P. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach. J Med Chem. 2010 Jun 10;53(11):4522-30. doi: 10.1021/jm100326d. PMID: 20462258.
