Bosentan hydrate(Ro 47-0203)波生坦水合物 endothelin-1(ET)拮抗剂|CAS 157212-55-0（53675ES）

Bosentan hydrate (Ro 47-0203)，又称波生坦水合物，是血管收缩药，是一种磺酰胺衍生的、竞争性endothelin-1 (ET)拮抗剂，靶向ET-A/B，K_i分别为4.7 nM和95 nM，可用于治疗血管痉挛相关疾病。

参考文献

1.Dhillon S, et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50.

2.Akamata K, et al. Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis Res Ther. 2014 Apr 3;16(2):R86.

3.Iglarz M, et al. Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension. Life Sci. 2014 Nov 24;118(2):333-9.

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