Roxadustat (FG-4592, FG4592)，又称罗沙司他，是可口服的HIF-PH抑制剂，抑制转录因子HIF-2降解，进而诱导内源性促红细胞生成素EPO产生，促进铁的吸收利用，临床上耐受性好，可用于治疗贫血症。

参考文献

1.Provenzano R, et al. Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving MaintenanceHemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study. Am J Kidney Dis. 2016 Jun;67(6):912-24.

2.Wu K, et al. Stabilization of HIF-1α by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury. Brain Res. 2016 Feb 1;1632:19-26.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。