Cidofovir (GS 0504, GS0504, HPMPC, (S)-HPMPC),又称西多福韦、培哚普利叔丁胺盐或昔多呋韦,是一种无环单磷酸核苷酸类似物,一种可注射的抗病毒药。Cidofovir可通过抑制病毒DNA的合成来抑制巨细胞病毒(CMV)复制,是抗CMV新药。Cidofovir对其它病毒感染,如正痘病毒、天花病毒、单纯疱疹病毒等。
参考文献
[1].David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403.
[2].M Bray, et al. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge. J Infect Dis. 2000 Jan;181(1):10-9.
[3].Simona Catalani, et al. Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir. Toxicol In Vitro. 2017 Jun;41:49-55.
[4].Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23.
冰袋运输。粉末直接保存于-25~-15℃,有效期3年。建议干燥保存,避免反复冻融。