Loureirin B（龙血素B）是从剑叶龙血树中提取的一种类黄酮化合物，是 PAI-1的抑制剂，IC₅₀值为26.10 μM。Loureirin B可通过调控MMPs和TIMPs的水平下调成纤维化相关分子p-ERK和p-JNK的表达，还能抑制K_ATP 通道和ERK、JNK的磷酸化，抑制瘢痕成纤维细胞增殖，抑制TGF-β 1诱导的细胞纤维化，具有镇痛，消炎等作用。

参考文献

[1]. He T, et al. Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β 1-ERK/JNK Pathway. Cell Physiol Biochem. 2015;37(2):666-76.

[2]. Sumsakul, Wiriyaporn, Wiratchanee Mahavorasirikul, and Kesara Na‐Bangchang. "Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450." Phytotherapy Research (2015). PMID:26490449.

[3]. Bai X, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24(5):355-60.

[4]. Sha Y, et al. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium. J Cell Biochem. 2017 Aug 17.

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