AEE788 (NVP-AEE788)是一种高效的EGFR、VEGFR和HER2/ErbB2抑制剂，其对EGFR和ErbB2的IC₅₀值分别为2 nM和6 nM，AEE788也抑制Flt-1、KDR、c-Src和c-Abl，其作用得IC₅₀值为50-80 nM。AEE788抑制EGFR和Akt的磷酸化，抑制肿瘤细胞增殖。 

参考文献

[1]. Traxler P, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004 Jul 15;64(14):4931-4941.

[2]. Park et al. AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. Clin Cancer Res. 2005 Mar 1;11(5):1963-1973.

冰袋运输。粉末直接保存于-20℃，有效期3年。溶于DMSO。建议分装后-20℃避光保存，避免反复冻融。