重组食蟹猴TL1A蛋白(His标签) Cynomolgus TL1A Protein（94078ES）

Tumor necrosis factor (TNF)-like cytokine 1A (TL1A) is a member of the TNF superfamily of proteins (TNFSF15), which signals through association with death domain receptor 3 (DR3). Decoy receptor 3 (DcR3) competes with DR3 for TL1A binding and inhibits functional signaling. These proteins are significantly upregulated in inflamed intestinal tissues, and their pathogenetic importance for inflammatory bowel disease (IBD) is suggested by accumulating evidence.TL1A/DR3 induce costimulatory signals to activated lymphocytes, including the gut-specific populations of CD4+CD161+ and CD4+CCR9+ cells, affecting all majoreffector pathways and inducing the mucosal upregulation of Th1, Th2, and Th17 factors.

高纯度、高活性、低内毒素、高批间一致性

SDS-PAGE

Figure 1. On SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA

Figure 2.Cynomolgus TL1A Protein; His Tag was immobilized at 5 μg/ml (100 μL/well). Increasing concentrations of Monoclonal Anti-HumanTNFSF15(TL1A) hIgG1 Antibody were added.

-85 ~ -65℃保存，收到货之日起，6个月有效期。避免反复冻融，建议等分分装为一次实验使用量，分装后，-80℃冻存。