Nutlin-3 (Nutlin3)是一种可通透细胞膜的MDM2抑制剂，IC₅₀为90 nM。

参考文献

1.Vassilev LT, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8.

2.Thompson T, et al. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem. 2004 Dec 17;279(51):53015-22.

3.Laurie NA, et al. Inactivation of the p53 pathway in retinoblastoma. Nature. 2006 Nov 2;444(7115):61-6.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。