iCRT3 (iCRT-3)是Wnt/β-catenin信号的抑制剂，属于恶唑类小分子，在Wnt responsive STF16-luc reporter assays中IC50为8.2 nM。iCRT3与β-catenin相结合，干扰其与TCF的相互作用，抑制β-catenin应答转录。Wnt信号调节大量的基本发育和细胞生物学过程，异常或持续的Wnt信号与多种肿瘤有关。

参考文献

1. Xiao H, et al. A Novel Positive Feedback Loop Between NTSR1 and Wnt/β-Catenin Contributes to Tumor Growth of Glioblastoma. Cell Physiol Biochem. 2017 Oct 24;43(5):2133-2142.
2. Chatterjee SS, et al. Inhibition of β-catenin-TCF1 interaction delays differentiation of mouse embryonic stem cells. J Cell Biol. 2015 Oct 12;211(1):39-51.
3. Sharma A, et al. Mitigation of sepsis-induced inflammatory responses and organ injury through targeting Wnt/β-catenin signaling. Sci Rep. 2017 Aug 23;7(1):9235.

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