Pimozide（又名Neoperidole; Pimozidum; NSC170984; NSC-170984; Orap; R 6238; R-6238; 匹莫齐特; 匹莫奇特）是dopamine receptor拮抗剂，D2受体拮抗剂，STAT3/STAT5抑制剂，二苯基丁基哌啶衍生物和具有抗精神病特性的多巴胺拮抗剂。Pimozide选择性地抑制中枢神经系统(CNS)中的2型多巴胺能受体，从而抑制多巴胺神经传递并减少运动发声抽动和妄想的发生。Pimozide对α1-adrenoceptor有较高亲和性，K_i值为39 nM。此外，Pimozide拮抗α-肾上腺素能受体和5-HT 2受体。Pimozide与5-HT 7受体具有高亲和力(Ki= 0.5 nM)。Pimozide降低STAT5酪氨酸磷酸化，可用于治疗精神障碍，抗精神病药，还可抑制多种癌细胞增殖，如结直肠癌，人骨肉瘤和肝细胞癌等。

参考文献

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