Bruceine D 鸦胆子苦素D(Bruceine-D) Notch抑制剂/细胞凋亡诱导剂|CAS 21499-66-1（53106ES）

Bruceine D是一种具有抗癌活性的Notch抑制剂，可诱导癌细胞凋亡。Bruceine D作用于线粒体诱导细胞凋亡，抑制细胞毒性，也能用作新型杀虫剂，具有很强的抑制害虫生长繁殖的作用。

参考文献

[1]. Fan J, Ren D, Wang J, Liu X, Zhang H, Wu M, Yang G. Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo. Cell Death Dis. 2020 Feb 18;11(2):126. doi: 10.1038/s41419-020-2317-3. PMID: 32071301; PMCID: PMC7028916.

[2]. Cheng Z, Yuan X, Qu Y, Li X, Wu G, Li C, Zu X, Yang N, Ke X, Zhou J, Xie N, Xu X, Liu S, Shen Y, Li H, Zhang W. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205. doi: 10.1016/j.canlet.2017.06.014. Epub 2017 Jun 20. PMID: 28645563.

[3]. Xie JH, Lai ZQ, Zheng XH, Xian YF, Li Q, Ip SP, Xie YL, Chen JN, Su ZR, Lin ZX, Yang XB. Apoptosis induced by bruceine D in human non‑small‑cell lung cancer cells involves mitochondrial ROS‑mediated death signaling. Int J Mol Med. 2019 Dec;44(6):2015-2026. doi: 10.3892/ijmm.2019.4363. Epub 2019 Oct 3. PMID: 31638181; PMCID: PMC6844635.

[4]. Tan B, Huang Y, Lan L, Zhang B, Ye L, Yan W, Wang F, Lin N. Bruceine D induces apoptosis in human non-small cell lung cancer cells through regulating JNK pathway. Biomed Pharmacother. 2019 Sep; 117:109089. doi: 10.1016/j.biopha.2019.109089. Epub 2019 Jun 19. PMID: 31226632.

[5]. Yang Y, Kong F, Ding Q, Cai Y, Hao Y, Tang B. Bruceine D elevates Nrf2 activation to restrain Parkinson's disease in mice through suppressing oxidative stress and inflammatory response. Biochem Biophys Res Commun. 2020 Jun 11;526(4):1013-1020. doi: 10.1016/j.bbrc.2020.03.097. Epub 2020 Apr 19. PMID: 32321640.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。